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KMID : 0385219920020020153
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Korean Journal of Gerontology
1992 Volume.2 No. 2 p.153 ~ p.159
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Effects of Acute and Chronic L-Ascorbic Acid Administration on Red Blood Cell Hemolysis and Tissue Lipid Peroxide Levels in Rats
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Lim Hye-Sun
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Abstract
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The effects of acute and chronic excess L-ascorbic acid(AsA) administration on red cell hemolysis and tissue lipid peroxide levels in rats were investigated. In the acute, intraperitoneal single injection of 100 mg AsA per 100 g body weight greatly lowered hemolysis at 1⅓ and 2 hours after the injection, but after 4 hours this lowering effect was disappeared. Plasma lipid peroxide level was also lowered, showing the similar time phase to the hemolysis. Plasma AsA value was highly elevated to about 10 times of the control after 1⅓ and 2 hours and dropped to near the control after 4 hours. Hepatic lipid peroxide level showed slight but significant decrease only after 4 hours, although highly raised hepatic AsA value was maintained until after 4 hours. In the chronic, 100㎎ AsA 100 g body weight were intraperitoneally injected once every two days during two weeks. After 2 weeks, plasma lipid peroxide level was markedly decreased in accordance with the acute. Plasma AsA value was slightly increased. However hemolysis did not show any significant modification comparing to the control. Rather hemolysis showed significantly strong positive correlation with plasma AsA value, suggesting chronic AsA administration promoted hemolysis on the contrary to the acute.
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KEYWORD
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L-ascorbic acid, red cell hemolysis, lipid peroxide, acute and chronic
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